Cannabidiol is an Allosteric Modulater at Mu- and Delta-Opioid Receptors

The mechanism of action of cannabidiol, one of the major constituents of cannabis, is not well understood but a noncompetitive interaction with mu opioid receptors has been suggested on the basis of saturation binding experiments. The aim of this study was to examine whether cannabidiol is an allosteric modulator at this receptor, using kinetic binding studies.