Cannabinoid WIN-55, 212-2 Mesylate Inhibitors Tumor Necrosis Factor-Alpha-Induced Expression of Nitric Oxide Synthase in Dorsal Root Ganglion Neurons

Tumor necrosis factor-a (TNF-a) is an established pain modulator in the peripheral nervous system. Elevated levels of TNF-a in dorsal root ganglion (DRG) neurons reportedly is critical for neuropathic pain processing. It has been shown that the production of nitric oxide, a key player in the development and maintenance of nociception, depends on the expression of nitric oxide synthases (NOSs) and their activities.