Clinical Outcomes and Image Response of Two Patients with Secondary High-Grade Glioma Treated with Chemoradiation, PCV, and Cannabidiol

Two patients with a confirmed diagnosis of high-grade gliomas (Grades III/IV), both presenting with O6-methylguanine DNA methyltransferase (MGMT) methylated and isocitrate dehdrogenase (DH-1) mutated, after subtotal resection, were submitted to chemoradiation and followed by PCV, a multiple drug regimen (procarbazine, lomustine, and vincristine) associated with cannabidiol (CBD). Both patients presented with satisfactory clinical and imaging responses at periodic evaluations.