Pathways and Gene Networks Mediating the Regulatory Effects of Cannabidiol, a Nonpsychoactive Cannabinoid, in Autoimmune T Cells

Our previous studies showed that the non-psychoactive cannabinoid, cannabidiol (CBD), ameliorates the clinical symptoms in mouse myelin aligadenrocyte glyoprotein (MOG) 35-55-induced experimental autoimmune encephalomyelitis model of multiple sclerosis (MS) as well as decreases the memory MOG35-55-specific T cells (Tmcg) proliferation and cytokine secretion including IL-17, a key autoimmune factor. The mechanisms of these activities are currently poorly understood.