Therapeutic application of cannabidiol on UVA and UVB irradiated rat skin. A proteomic study

UV phototherapy used in chronic skin diseases causes redox imbalance and pro-inflammatory reac-tions, especially in the case of unchanged skin cells. To prevent the harmful effects of UV radiation, cannabidiol (CBD) has been used, which has antioxidant and anti-inflammatory properties. Therefore, the aim of this study was to evaluate the effect of CBD on the metabolism of skin keratinocytes in nude rats exposed to UVA/UVB radiation using a proteomic approach.